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Check Closely (3)pentobarbital will lessen the level or outcome of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Solid or moderate CYP3A4 inducers may well maximize charge of diazepam elimination; consequently, efficacy of diazepam could possibly be decreased.fentanyl transmucosal and pentobarbit